The PGE2 secreted by these newly located cells functions on intestinal stem cells or intestinal progenitor cells by way of EP2 or EP4 to advertise their differentiation into wound-relevant epidermal cells. (B) Throughout tissue mend, PGE2/EP4 promotes the proliferation of intestinal stem cells as well as the formation of intestinal epithelial cells
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Background Persistent activation of fibroblast with abnormal launch of extracellular matrix is a trademark of systemic sclerosis (SSc). Fibroblasts can either obtain a “pro-fibrotic” phenotype with abnormal matrix output or maybe a “Professional-inflammatory” phenotype with releasing of matrix-degrading enzymes and subsequent tissue destruc